Landscape properties, such as slope and curvature, along with soil physical properties, such as organic matter content, texture, and their distribution among horizons, naturally vary within fields. These natural properties interact with management of nitrogen (N) fertilizer and irrigation to control availability of N and water to the growing crop throughout the growing season. This project evaluated these interactions at four locations in Nebraska in 2011, with the objective of providing recommendations to the increasing number of producers with capacity for both variable rate N fertilizer and variable rate irrigation. Treatments varied with location, but were designed to investigate interactions of water and N supply on water and N use efficiency, as well as landscape position interactions at selected sites. Two sites included interactions of landscape position, water rate and N rate; one site evaluated interactions of water and N rate; one site evaluated interactions of landscape position and N rate. Soil water at multiple depths was regularly monitored at all sites throughout the growing season. Crop canopy properties (reflectance, temperature, height) were monitored at two week intervals. Grain yield was measured with yield mapping combines, in conjunction with hand-harvested locations for local calibration. Reported information will include interactions of landscape properties, soil water status, and N supply on grain yield, N and water use efficiency, and crop canopy properties.