Wild blueberry producers apply agrochemicals uniformly without considering substantial variation in soil properties, topographic features that may affect fruit yield within field. A wild blueberry field was selected to evaluate the impact of variable rate (VR) fertilization on nutrient losses in surface runoff from steep slope to low lying areas to improve crop productivity. Field was divided into three sections (variable rate application, VRA; uniform application, UA; and control) and three management zones (steep slope, Z1; moderate, Z2 and low lying area, Z3) were developed in each section based on slope variation and bare spots in the field. GPS-guided prescription map was developed in ArcGIS 9.3 to apply fertilizer rates (200,150 and 100 kg ha^-1 for Z1, Z2, Z3, respectively) with VR fertilizer spreader and zero rate was allocated for bare spots. One section received the growers uniform fertilizer rate of 200 kg ha^-1 for comparison. USDA-NRCS runoff plots were installed to collect surface runoff samples from different zones of the field. The surface runoff samples were collected from USDA-NRCS runoff plots after every heavy rainfall event and analyzed for total phosphorus (TP), dissolved reactive phosphorus (DRP), and inorganic nitrogen concentrations. The leaf samples were analyzed for leaf nutrient concentrations under VRA and UA. The VRA significantly (p≤0.05) decreased TP, DRP, and inorganic nitrogen losses in surface runoff as compared to UA in low lying area of the field. Most leaf nutrient concentrations were not significantly influenced by the VRA and were within the recommended optimal ranges. VRA used 40% less fertilizer than standard UA and could improve crop productivity.