Nematode distribution varies significantly in cotton fields. Population density throughout a field is highly correlated to soil texture. Field-wide application of a uniform nematicide rate results in the chemical being applied to areas without nematodes or where nematode densities are below an economic threshold, or the application of sub-effective levels in areas with high nematode densities. The investigators have developed a “Site- Specific Nematicide Placement” (SNP) system that is ready for commercial deployment and use by growers. The SNP system consists of the following components: I) Generating management zones based on inexpensive geo-referenced field soil texture map using a mobile soil electrical conductivity meter; II) The soil EC zones are then used to develop a nematode management map for each field based on targeted sampling for assay and quantification of nematode population densities; III) Geo-referenced nematicide application prescription maps are generated based on nematode assays; and IV) Nematicides are applied to the field site-specifically as appropriate for each management zone using GPS-guided equipment.   This paper presents the results of efforts in South Carolina, Arkansas and Louisiana to further develop and refine this system for the effective delivery of nematicides in a site-specific, variable-rate manner in individual cotton fields.