With the cost of agricultural inputs and the instability of commodity prices increasing, demand is growing for training in the essential skills needed to successfully implement site-specific crop management. This set of skills is uniquely interdisciplinary in nature. Thus, it is essential for potential users of precision agriculture to understand the basics of geodetic and electronic control equipment, principles of geographic information systems, fundamentals of geostatistics and production economics, elements of soil fertility and other aspects of crop production, and logistics of modern farming operations. Our core undergraduate course is called Site-Specific Crop Management and is cross-listed under the Agronomy, Mechanized Systems Management, and Agricultural Engineering majors. In addition, we teach a graduate distance education course on spatial variability in soils. This paper outlines major challenges and solutions regarding the interdisciplinary nature of precision agriculture education.