Symptoms of red stripe disease caused by Acidovorax avenae subsp. avenae in Louisiana between 1985 and 2010 were limited to the leaf stripe form which caused no apparent yield loss.  During 2010, the more severe top rot form was observed, and a study was initiated to investigate the distribution of red stripe in the field and determine its effects on cane and sugar yields. Two fields of cultivar HoCP 00-950, one plant-cane (PC) crop and one first-ratoon (FR) crop, affected by top rot were subdivided into 113 and 84 plots, respectively.  Each field was grid-soil sampled (at several intensities) and red stripe ratings were collected at each point at two separate times.  Soil properties exhibited significant variability (CV=6 - 64%) and were spatially correlated in 12 of 28 cases with a range of spatial correlation varying from 43 to 95-m.  Red stripe ratings were also highly variability with a CV ranging from 65 to 92% and were spatially correlated in 3 out of 4 cases with a spatial range of 19 to 84-m.  Sugarcane yields exhibited a CV ranging from 6 to 26% and were spatially correlated in 4 out of 6 cases with a range varying from 6 to 49-m.  Red stripe ratings were correlated with several soil properties, when locations were combined, including phosphorus, potassium, calcium, copper, zinc and CEC.  Red stripe ratings were also significantly correlated with sugarcane yields, most notably TRS (r = -0.34^*** to -0.61^***) and sugar per hectare (r = -0.21^** to -0.36^***).  Contour plots of soil properties and red stripe ratings levels also clearly suggested a link between several of these parameters.  These combined data suggest that red stripe disease can exhibit a variable rate of infection in commercial sugarcane fields and can also significantly decrease cane and sugar yields.  The rate of infection is influenced by soil properties and cultural practices, suggesting that proper management of these factors may help control the extent and spread of the disease.